congestive heart failure — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5329	Trandolapril		Angiotensin-converting Enzyme (ACE)
	Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.		Angiotensin-converting Enzyme (ACE)
T0154	Nebivolol hydrochloride	R 065824 hydrochloride,Nebivolol HCl,R-65824	Apoptosis , Adrenergic Receptor
	Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us...		Apoptosis , Adrenergic Receptor
T1462	Captopril	SQ 14225,SQ-14534,SA333	RAAS
	Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.		RAAS
T0342	Carvedilol phosphate hemihydrate	Carvedilol phosphate,BM 14190 (phosphate hemihydrate)	VEGFR , Others , Potassium Channel , LDL , Integrin , Gap Junction Protein , NADPH , Adrenergic Receptor , Autophagy
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom...
T33600L	(Rac)-Naxifylline	(Rac)-Naxifylline（(Rac)-166374-49-8）	Others
	(Rac)-Naxifylline may be used to study congestive heart failure.		Others
T3212	Digoxigenin		Others
	Digoxigenin, a therapeutic drug belonging to the group of cardiac glycosides, is widely used in the management of congestive heart failure and other cardiac diseases		Others
T27596	Imazodan hydrochloride	CI914 HCl,CI-914 HCl,CI 914 HCl,Imazodan HCl	PDE
	Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.		PDE
T6595	Moexipril hydrochloride	Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis , RAAS
	Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.		Apoptosis , RAAS
T1182	Levocarnitine propionate hydrochloride	Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,ST-261	Histamine Receptor
	Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.		Histamine Receptor
T1694	Oxypurinol	Oxipurinol	ROS , Xanthine Oxidase , Endogenous Metabolite
	Oxypurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.		ROS , Xanthine Oxidase , Endogenous Metabolite
T16782	Rolofylline	KW-3902,MK-7418,KF-15372	Adenosine Receptor
	Rolofylline (KW-3902) is a selective adenosine A1 receptor antagonist used in the study of acute congestive heart failure and renal dysfunction, and in the study of neurodegenerative disorders.		Adenosine Receptor
T27119L	(Rac)-Daglutril	SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid	Others
	(Rac)-Daglutril (SLV 306 acetic acid) is the racemate form of Daglutril. Daglutril is an orally active, mixed neutral endopeptidase/endothelin converting enzyme inhibitor under development for the treatment of essential ...		Others
T1670	Lanatoside C	Cedilanid,Ceglunate,Isolanid	ATPase , Virus Protease , Autophagy
	Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intrav...		ATPase , Virus Protease , Autophagy
T0805	Quinapril hydrochloride	CI-906,PD-109452-2,Quinapril HCl	RAAS
	Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transie...		RAAS
T8462	Enoximone		PDE
	Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.		PDE
T2530	Levosimendan	OR1259,OR1855	Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
	Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without ...		Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
T8183	Deslanoside	Desacetyllanatoside C,Deacetyllanatoside C	ATPase , Drug Metabolite
	Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane p...		ATPase , Drug Metabolite
T16444	PD-118057		Potassium Channel , HER
	PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential ...		Potassium Channel , HER
T35336	Furosemide sodium	Frusemide Sodium,Lasix	Na-K-Cl cotransporter
	Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity ...		Na-K-Cl cotransporter
T13599	Benzofurodil	CB4091,Benfurodil,Eudilat	Others
	Benzofurodil is cardiotonic used for the chronic treatment of congestive heart failure.		Others